A nationwide study in the USA has found that amyloid PET significantly influences clinical management, including the use of medications and counselling, of patients with mild cognitive impairment (MCI) or dementia. Changes in management were observed in about 60% of...
First-ever effective treatment of Charcot-Marie-Tooth disease type 1a
PXT3003 is the first treatment for Charcot-Marie-Tooth disease type 1a (CMT1A) that is effective, safe, and well tolerated. This was demonstrated in the pivotal phase 3 trial PLEO-CMT. PXT3003 is a novel oral fixed-dose combination of baclofen, naltrexone, and D-sorbitol,...
Ibudilast affects brain atrophy in PPMS, not SPMS
In the randomised phase 2 trial SPRINT-MS, the effect of ibudilast on brain measures of integrity was evaluated in both primary and secondary progressive MS (PPMS and SPMS). Results of a post-hoc analysis suggested that the effect of ibudilast on...