In the randomised phase 2 trial SPRINT-MS, the effect of ibudilast on brain measures of integrity was evaluated in both primary and secondary progressive MS (PPMS and SPMS). Results of a post-hoc analysis suggested that the effect of ibudilast on...
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Post-study immunotherapy confounds primary survival outcome
An exploratory analysis of the phase 3 MYSTIC trial suggests that the high rate of subsequent post-study immunotherapy received by patients with metastatic non-small cell lung cancer (NSCLC) who previously received chemotherapy, confounded the primary overall survival (OS) outcome. Durvalumab...
Head-to-head comparison of two ALK inhibitors
Brigatinib showed a statistically and clinically relevant improvement in PFS vs crizotinib in patients with anaplastic lymphoma kinase (ALK) inhibitor-naïve, ALK-positive non-small cell lung cancer (NSCLC). This was the result of the first interim analysis from the ALTA-1L study comparing the...
Reduction in coronary artery disease in psoriasis patients treated with biologic therapies
Treating psoriasis with biologic drugs that target the immune system can reduce early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The association between psoriasis and occlusive cardiovascular events was noted originally nearly...
Secukinumab maintains improvements in psoriasis through 5 years of treatment
At the 2019 AAD meeting, 5-year follow-up data from the extension cohort of the phase 3 core trials ERASURE/FIXTURE was presented that showed that the IL-17A blocker secukinumab maintains long-term high levels of efficacy[1, 2]. Patients from the ERASURE/FIXTURE trials...
DNA of sperm taken directly from testicles of infertile men is “as good as sperm from fertile men”, possibly opening way for new treatment
Sperm DNA from the testicles of many infertile men is as good as that of ejaculated sperm of fertile men. This may explain a major cause of male infertility and opens the possibility of using sperm taken directly from the...