Reduction in coronary artery disease in psoriasis patients treated with biologic therapies

Treating psoriasis with biologic drugs that target the immune system can reduce early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The association between psoriasis and occlusive cardiovascular events was noted originally nearly 50 years ago [1], and it is generally attributed to the heightened systematic inflammation present in psoriasis patients, which results in excess low-density lipoproteins lining the arteries. What was not yet known was whether modulating the inflammatory condition with immunotherapy would result in reduced risk of cardiovascular disease.

Dr Nehal Mehta (National Heart, Lung, and Blood Institute, NIH, USA) presented the just-published results of the first in-human evidence that treating psoriasis patients with biologic systemic therapies has positive consequences on cardiovascular outcomes [2]. This prospective, observational study of the NIH Psoriasis Atherosclerosis Cardiometabolic Initiative cohort included 290 psoriasis patients, 121 of whom suffered moderate-to-severe skin disease and qualified for the biologic therapy according to treatment guidelines. For a year, Mehta and colleagues followed the entire cohort, all of whom had low cardiovascular risk at baseline, and compared the patients on biological treatments to those who did not receive biologic therapy. High-risk coronary plaque phenotypes were measured by coronary computed tomography angiography. A blinded reader (blinded to patient demographics, visit, and treatment), quantified total coronary plaque burden, and plaque subcomponents (calcified and non-calcified) in the 3 main coronary vessels >2 mm. Study results show that biologic therapy was associated with an 8% reduction in coronary artery plaque, while other changes in other cardiovascular risk factors such as cholesterol, glucose, and blood pressure were unchanged. “The findings that intrigued us most were that coronary plaque sub-components changed over 1 year, including the necrotic core and non-calcified components, which are the culprits for most heart attacks,” Mehta said. These findings highlight that using biologic therapies to reduce the underlying inflammatory disease in patients has benefits in secondary complications, such as coronary artery disease, in particular of rupture prone plaque. However, it should be noted that this data is observational at this point, necessitating the initiation of randomised, controlled trials.

  1. McDonald CJ, Calabresi P. Occlusive vascular disease in psoriatic patients. N Engl J Med. 1973 Apr 26;288(17):912.
  2. Elnabawiet al. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019 Mar 15;115(4):721-728.

The content and interpretation of these conference highlights are the views and comments of the speakers/authors.


  1. JamesJoype

    Koh Samui is an ideal place for exploring yoga due to the outstanding natural beauty of the island. Most of Koh Samui is still considered unspoiled and unpolluted. Time on Koh Samui is an opportunity to relax, unwind, explore and focus on yourself. Enjoy the natural energy of palm trees, white sand, purple sunsets, turquoise waters, dense jungle, and exotic waterfalls. Despite being so easily accessible, Samui remains an idyllic island in the sun. Koh Samui is easily reached via an increasing number of direct international flights and over a dozen daily 1-hour flights from Bangkok. Arrive easily with a direct flight from any Asian hub on Bangkok Airways. Our award winning airport will receive you with a selection of shopping and eating options making flying in or out of Samui a breeze. If you’re traveling on a budget, and feeling brave, you can also reach the island via ferry from the mainland Thai city of Surat Thani. Be sure to check ferry times as the schedules are sometimes limited. Vikasa is just a fifteen minute drive from the Samui Airport. Airport pick-up is provided but not complementary for all guests, please for more information get in contact with us. Vikasa Yoga retreat in Thailand is much more than just a hotel with yoga. Vikasa Yoga Re­treat is a transformational, inspiring, and life-changing experience and one of the most reputable places to learn and practice yoga in Thailand. Our rooms are modest, yet comfortable and clean. The landscape and the surroundings are absolutely stunning, there are no words to describe them. You will have to climb a lot of stairs, but the view from the top is so worth it. You might make discoveries here that will create a major shift in your consciousness and even be the beginning of a major change in your lifestyle. And you will definitely meet some amazing people and make some new friends for life.

  2. WilliamPlorm

    amoxicillin 500mg capsule buy amoxil – amoxicillin 500mg prescription

  3. Williamleami

    plaquenil 300 buy plaquenil – plaquenil 200 mg online

  4. Williamleami

    plaquenil price canada buy plaquenil – hydroxychloroquine sulfate 200mg tablet

  5. hydroxychloroquine dosage chart for humans

    Reduction in coronary artery disease in psoriasis patients treated with biologic therapies – Medicom Medical publishers

  6. MarioDrade

    ivermectin 3mg tablets price stromectol – stromectol 3mg

Leave a Reply

Your email address will not be published.